Each category has at least one description. This pathway supplies ribose sugar for the formation of the nucleotide. sary for the synthesis of RNA, DNA, nucleotide-activated sugars, and lipids [3]. Understand the Two Pathways of nucleotide biosynthesis (1) De-novo synthesis and (2) Salvage Pathways. The salvage of pyrimidine bases has less clinical significance than that of the purines, owing to the solubility of the by-products of pyrimidine catabolism. A salvage pathway is a pathway in which a biological product is produced from intermediates in the degradative pathway of its own or a similar substance. In this system, both the salvage precursors [ 3 H]thymidine and [ 14 C]cytidine were incorporated actively into skin DNA and only [ 14 C]cytidine into skin RNA. The abbreviation PRPP is used for 5-phosphoribosyl-1-pyrophosphate. The purine ring is synthesized along with the nucleotide i.e. De novo synthesis of nucleotides does not take place in brain and erythrocytes, making salvage pathway indispensable for them The salvage pathway requires no ATP and accounts for 90% of nucleotide biosynthesis. Classify each description as the de novo pathway, salvage pathway, or both pathways of pyrimidine nucleotide synthesis. recycling of the bases. I. De-novo synthesis (synthesis from scratch): it is a biochemical pathway in which nucleotides are synthesized new from simple precursor molecules. However, as indicated above, the salvage pathway to thymidine nucleotide synthesis is especially important in the preparation for cell division. (1) de-novo synthesis and (2) synthesis by salvage pathways. Nucleotide Synthesis (De-novo and Salvage Pathways of Purine & Pyrimidine Biosynthesis PPT by easybiologyclass) 1. NUCLEOTIDE BIOSYNTHESIS Bio-synthesis of Purines & Pyrimidines e-mail: easybiologyclass@gmail.com mail@easybiologyclass.com www.easybiologyclass.com www.easybiologyclass.com Both purines and pyrimidines can be synthesized by 2 alterative pathways: the de novo pathways that metab-olize ribose and amino acids in a series of enzymatic reactions and the salvage pathways that Salvage pathway (recycle pathway): used to recover bases and nucleosides formed during the degradation of RNA and DNA APRT is inhibited by AMP. De Novo Synthesis: De novo (all over again) synthesis of purine nucleotides is synthesis of purines anew. II. attached to the ribose sugar provided from HMP pathway. The pyrimidine synthesis is a similar process than that of Purines(Purines Synthesis).In the de novo synthesis of Pyrimidines, the ring is synthesized first and then it is attached to a ribose-phosphate to for a pyrimidine nucleotide.Pyrimidine rings are assembled from bicarbonate, aspartate, and Ammonia. 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