List of various diseases cured by Vitex Trifolia. Medicinal Plants Medicinal plants and their uses (medicinal herbs) Home » Medicinal and Aromatic Plants » Round Leaf Chastetree, Beach Vitex. Recipient(s) will receive an email with a link to 'Beach Vitex (Vitex rotundifolia): Medicinal Properties, Biology, Invasive Characteristics and Management Options1' and will not need an account to access the content. For its efficient use and conservation, genetic diversity and clonal variation of V. rotundifolia populations in China were investigated using inter‐simple sequence repeat markers. Uses, Benefits, Cures, Side Effects, Nutrients in Vitex Trifolia. All compounds showed good inhibition of ROS, IL-8 and TNF-α with the IC50 values ranging from 3.4 to 38.5 μM. While the plant is a seashore obligate, it grows over a wide latitude range. Representatives of fluorenone natural products. Medicinal Plants in Papua New Guinea Publication Author Publisher World Health Organisation Year 2009 ISBN 978-92-9061-249-0 Description Traditional medicinal uses of 126 species from Papua New Guinea, including information on any modern research into the plants. It is used in the treatment of Vata and Kapha. 30. 2007), allergies (Shin et al. Normally, the multiple substituted hydroxyl groups cause the high oxidation state of related molecules. Monte Carlo simulation results (N=5,000) for uncertainty around the risk scores for Vitex rotundifoliaa. Vitex rotundifolia, commonly known as beach vitex, is a low, woody, perennial shrub with branches that can run for many meters. Research has shown that the drosera rotundifolia plant is an effective anti-inflammatory. The Vitex negundo linn is another Indian plant, which have enormous traditional uses against various diseases. Compounds 135 exhibited the highest inhibitory action with the IC50 value of 2.2 μg/mL followed by (133) 3.5, (129) 4.1, (121) 4.3, (132) 5.2, (126) 5.3, (134) 6.1, (127) 6.6, (130) 7.3, (128) 7.4, (131) 9.2, (123), 9.6 (125), 10.3, (124) 12.1 and (122), 12.8 μg/mL, respectively. This compound was one of the 18 responsible for the cytotoxicity against five cultured human tumor cell lines, that is, A549 (non-small cell lung), SK-OV-3 (ovary), SK-MEL-2 (melanoma), XF498 (central nerve system), and HCT-15 (colon). Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, People's Republic of China . Amidinophenyl-substituted furans 1–5, and their derivatives, have been shown to be active against Trichomonas vaginalis<2005WO2005086754>. The geranyl flavones namely paulownione C (181) and tomentodiplacone O (182) were isolated from the fruits of the Paulownia tomentosa. Be sure to keep the medium moist. J Nat Prod. As a result, fluorenones are easily oxidized in air. . obovata: Common Name: Round-Leaved Chaste Tree, Single-Leaf Chastetree: Explore more topics. Different species of Vitex vary in chem … Vitex negundo and its medicinal value Mol Biol Rep. 2018 Dec;45(6):2925-2934. doi: 10.1007/s11033-018-4421-3. Be sure to keep the medium moist. The representatives of fluorenone containing natural products are shown in Fig. BV may also be used in the treatment of allergies, antibiotic-resistant bacteria, and pain. Homeopathic usage of the treatment accounts for most of its medicinal usage, and it can also be prescribed for other conditions, such as the patient’s bed feeling too hard and cuts and scrapes. J Nat Prod. Asian J Tradit Med. People have also used these fruits as a folk medicine to treat chronic bronchitis, headache, migraine, cold, eye pain, asthma, female hormonal disorders, and gastrointestinal infections, including diarrhea and bacterial dysentery. All the isolated derivatives were assayed for their biological potential to check ability to inhibit COX-1, COX-2 and 5-LOX. Vitex rotundifolia risk score (black box) relative to the risk scores of species used to develop and validate the PPQ WRA model (other symbols). Vitex negundo (VN), commonly known as "chaste tree", is an ethnobotanically important plant with enormous medicinal properties. Pap. It has been used for medicinal purposes throughout its native range. Additionally, care must be taken to avoid secondary infestations from other invasive plants such as Similax sp following BV removal. More recently, it was imported to the eastern United States where it has become a seashore invasive. A prenylated flavonoid, neougonins A (186) was obtained from the Helminthostachys zeylanica, exhibited the inhibitory action on LPS-induced NO production with an IC50 value of 3.32 μM in RAW264.7 cells [220]. The seeds are difficult to remove from the fruit, but the entire fruit can be planted. [Google Scholar] 10. . Keay, ... P.W. Experiment Station; Professor Emeritus. Casticin, a flavonoid found in extracts of BV fruits, has demonstrated an ability to inhibit growth of human cancer cells. Vitex, or chaste tree (Vitex agnus-castus)—celebrated by women in ancient Greek festivals and on holy days as a symbol of marriage, chastity and fertility—gives contemporary women cause for celebration, too: it can safely and effectively relieve the monthly misery of difficult menstrual cycles. Ono M, Yanaka T, Yamamoto M, Ito Y, Nohara T. New diterpenes and norditerpenes from the fruits of Vitex rotundifolia. C. DC. The described compounds exhibit in vitro activity against metronidazole-sensitive and -resistant T. vaginalis isolates. Qiaoyan Zhang. Kanzonol C (44), isobavachalcone (45), stipulin (46), and 4-hydroxylonchocarpin (47) show broad-spectrum bacteriostatic activities against fungi, Gram-negative and Gram-positive bacteria. . Bernice P, IFAS Assessment of Non-Native Plants in Florida's Natural Area, In SS-AGR-86. Furan containing aminoalcohol 6 belongs to a class of pharmaceutical compounds for use as immunosuppressants for the treatment and/or prevention of rheumatoid arthritis, Crohn’s disease, ulcerative colitis, multiple sclerosis, psoriasis vulgaris, atopis cermatities, insulin-dependent diabetes, glomerulonephritis, and graft rejection. Man Jing Zi is also known as Vitex Fruit or Fructus Viticis and is the mature fruit of Vitex trifolia or Vitex rotundifolia. Genus Vitex is the Latin name used by Plinius for the chaste tree. Similarly, compound 182 exhibited excellent COX-2 inhibitory activity with the IC50 value of 9.5 μM [217]. Eupafolin (141) isolated from the methanolic extract of Chinese plant Phyla nodiflora displayed significant anti-inflammatory action in different bioassays. 2. Asian J Tradit Med. We use cookies to help provide and enhance our service and tailor content and ads. It is native to India and also found growing in Bangladesh, China, Philippines, Sri Lanka, and Japan. Vitex negundo is a medicinal tree. Biological examples show FBPase inhibition in human, rat, and mouse livers, inhibition of gluconeogenesis in rat hepatocytes, along with inhibition of glucose production. A number of compounds have been reported which contain a furan ring. Additionally, compounds 121, 129 and 135 expressively suppressed LPS-induced expression of COX-2 protein [206]. Interpreting Wetland Status. Vitex supplements typically contain extracts of the fruit and/or seed of the plant. Irritation or pain in the throat is commonly treated using drosera rotundifolia, but homeopaths also use the treatment for things such as a patient’s bed feeling too hard. Tax, “Kudzu of the beach” threatens Carolina Dunes, Engineer Update 28(2) U. S. Army Corps of Engineers, Scary species, superlative sites: assessing weed risk in New Zealand's protected natural areas, Biology and control of beach vitex and common reed, United States Department of Agriculture (USDA), USDA, ARS, National Genetic Resources Program, Germplasm Resources Information Network - (GRIN) [Online Database]. The inhibition of particulate matter (PM) induced COX-2 protein and PGE2 production in HaCaT cells was significantly observed by the Eupafolin. Similar Images . The metabolite 145–147, 151 and 154 exhibited significant inhibitory activity comparable to standard drug used quercetin (IC50 = 4.4 μM) with the IC50 values of 5.7 (145), 5.7 (146), 5.4 (147), 6.0 (151) and 3.4 μM (154), respectively [211]. See Appendix A for the complete assessment. Vitex negundo is indicated in Joint Disorder, Low Back Pain, Osteoarthritis, Rheumatoid Arthritis (Amavata), Sciatica, Spondylosis, and Vata Vyadhi. & A.L. 1. Fig. 2000), and pain (Hu et al. National Germplasm Resources Laboratory, Beltsville, Maryland. More Accounts and Images; ARS Germplasm Resources Information Network (VIRO80) CalPhotos (VIRO80) … All compounds displayed good inhibition against NO production in induced LPS with a concentration of 10 mM [207]. Five flavonoid glycosides (155–159) were isolated during phytochemical investigation of Chrozophora tinctorial. The process is repeated until the site has zero regrowth. Names of Vitex Trifolia in various languages of the world are also given. The inclusion complex of bromofuran 8 not only increased the aqueous solubility of the furan compound, but also the dissolution rate <2004JPS197>. Corresponding author's E-mail: twhtwll@clemson.edu. However, 164 and 167 displayed almost 10 times greater inhibition with compare to used standard, zileuton [213]. elicited apoptotic effects against a broad spectrum of leukemic cell lines, especially human lymphoma HUT78 and H9 cells, with IC50 values equal to 9.5 μg/mL and 6 μg/mL, respectively,152 by possible downregulation of c-Myc and therefore transcription.153 In addition, sclareol at a dose of 100 μM induced apoptosis in the human breast adenocarcinoma (MCF-7) cell-line variants MN1 (wild-type p53) and MDD2 (p53 null) independently of p53.154, The labdane diterpene myriadenolide (CS 2.79) from Alomia myriadenia Sch. Rightfully so. Although various synthetic strategies towards the fluorenone1c and azafluorenone9g,h were developed, but due to the relatively simple structures, research in this field mainly relies in the biological studies of the isolated natural products. Vitex rotundifolia risk score (black box) relative to the risk scores of species used to develop and validate the PPQ WRA model (other symbols). with MIC of 0.5, 1.0 μg/mL on Microsporum gypseum and Trichophyton mentagrophytes, respectively.123,124, Among other phenolic compounds, xanthones and quinones are known for their potent MRSA-inhibitory properties and are therefore considered as lead compounds for synthesizing new antibacterial agents.125–127 Mangostanin (31), a tetraoxygenated xanthone isolated from the fruit of Garcinia cowa, is a strong growth inhibitor against two penicillin-sensitive and methicillin-resistant strains of Staphylococcus aureus with MIC values of 4.0 μg/mL.128, In studies on the compounds of the roots of Cratoxylum formosum, several potent antibacterial xanthones have been isolated. Vitex rotundifolia can be propagated either by seed or by cuttings. The Chinese medicinal plant, Vitex rotundifolia led to the isolation of casticin (140) from its fruits. Dragonin A (183) and Dragonin B (184) displayed significant inhibition of superoxide anion induced by fMLP/CB with the IC50 values of 3.1 (183) and 1.3 μM (184), respectively [218]. The parched and powdered leaves have been used as a dressing on burns and scalds. Other descriptions of the leaf fragrance are black pepper, basil, minty, and fir trees or "like being in a forest." These are mainly originated in the flowers, fruits, barks, roots, stems, tea, wine and vegetables [202]. Quinone 9 was isolated along with two other quinones from the stem bark of Millettia versicolor. A wide variety of pharmaceuticals which incorporate a five-membered ring containing one oxygen atom have been prepared. PubMed:Estrogen-like activity of volatile components from Vitex rotundifolia L. PubMed:Evaluation of the estrogenic activity of the constituents in the fruits of Vitex rotundifolia L. for the potential treatment of premenstrual syndrome. A mature Vitex rotundifolia produces fragrant, blue-purple flowers that are borne in clusters and ultimately yield small purblish-black fruits. leaves, a. The species is hermaphrodite (has both male and female organs) and is pollinated by Insects. In human chronic myeloid leukemia (KBM-5) cells, coronarin D (CS 2.80) suppressed TNF-α-induced NF-κB activation at a dose of 10 μmol/L and inhibited NF-κB activation by abating IKKβ activation, resulting in the suppression of IκBα phosphorylation, p65 phosphorylation and nuclear translocation.156 The survival of multiple mouse myeloma (MOPC315) cells was severely compromised by the polyoxygenated labdane diterpene forskolin (CS 2.81) from Coleus forskohlii (Willd.) Vitex agnus-castus is a deciduous Shrub growing to 3 m (9ft) by 3 m (9ft) at a medium rate. Expose cambial vitex rotundifolia: medicinal uses in SS-AGR-86 the standard use incorporation of the azafluorenone ( Fig of.... 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